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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Fig. 5

Bilateral mechanical pain hypersensitivity following dIoN-CCI surgery in the wide-type and Tlr2−/− mice. a-b At 0.008 g stimulus intensity, ipsilateral (a) and contralateral (b) mechanical pain hypersensitivity induced by dIoN-CCI group was significantly inhibited in the Tlr2−/− mice compared with that of wild-type mice. c-d At 0.02 g stimulus intensity, ipsilateral (c) and contralateral (d) mechanical pain hypersensitivity induced by dIoN-CCI group was significantly inhibited in the Tlr2−/− mice compared with that of wild-type mice. Data was expressed as Mean ± SEM. (n = 6 each group, * P < 0.05, ** P < 0.01, *** P < 0.001 compared with the C57 dIoN-CCI group, two-way ANOVA with post-hoc Bonferroni test). dIoN-CCI, chronic constriction injury of distal infraorbital nerve; BL, baseline

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The Journal of Headache and Pain

ISSN: 1129-2377

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