Skip to main content
Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Fig. 3

Facial injection of BoNT/A attenuated dIoN-CCI surgery-induced anxiety-like behavior, but not depression-like behavior, in mice. On day 14 following dIoN-CCI surgery, BoNT/A was injected in dIoN-CCI mice. a In open field test, on day 5 after BoNT/A injection (day 19 following dIoN-CCI surgery), BoNT/A treatment significantly increase the time in the center area compared with that of vehicle group. b On day 5 after BoNT/A injection (day 19 following dIoN-CCI surgery), BoNT/A treatment significantly decrease the excretion rate compared with that of vehicle group. c-d In an elevated plus maze, on day 5 after BoNT/A injection (day 19 following dIoN-CCI surgery), BoNT/A treatment had no significant effect on the percentage of duration of open arms compared with that of vehicle group (c). BoNT/A treatment significantly increased the percentage of entries into the open arm in an elevated plus maze than that of vehicle group (d). e-f There was no significant change in the duration of the immobility time in FST test (e), the body weight (f) among the three groups during the experiment. Data was expressed as Mean ± SEM. (n = 8 each group, n.s., no significance, * P < 0.05, *** P < 0.001 compared with the sham group. # P < 0.05, ## P < 0.01, ### P < 0.001 compared with the dIoN-CCI group, unpaired Student’s t-test). dIoN-CCI, chronic constriction injury of distal infraorbital nerve; BoNT/A, botulinum toxin A; BL, baseline; FST, forced swimming test

Back to article page

The Journal of Headache and Pain

ISSN: 1129-2377

Contact us