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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Fig. 2

Unilateral facial injection of BoNT/A attenuated bilateral mechanical pain hypersensitivity induced by dIoN-CCI surgery in mice. Black arrow represented the time of BoNT/A injection in mice. a-b At 0.008 g von Frey stimulation intensity, facial injection of BoNT/A significantly attenuated ipsilateral (a) and contralateral (b) mechanical pain hypersensitivity induced by dIoN-CCI surgery in mice, which lasted approximately 9 days, compared to the vehicle group. After 2 weeks, a second injections of BoNT/A showed the similar analgesic effect. c-d At 0.02 g von Frey stimulation intensity, facial injection of BoNT/A significantly attenuated ipsilateral (a) and contralateral (b) mechanical pain hypersensitivity induced by dIoN-CCI surgery in mice, which lasted approximately 9 days, compared to the vehicle group. After 2 weeks, a second injections of BoNT/A showed the similar analgesic effect. Data was expressed as Mean ± SEM. (n = 8 each group, * P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA with post-hoc Bonferroni test). dIoN-CCI, chronic constriction injury of distal infraorbital nerve; BoNT/A botulinum toxin A; BL, baseline

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The Journal of Headache and Pain

ISSN: 1129-2377

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