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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

Fig. 1

Bilateral mechanical pain hypersensitivity during 5 weeks following dIoN-CCI surgery in mice. a-b At 0.008 g stimulus intensity, mechanical pain hypersensitivity in dIoN-CCI mice was observed in the ipsilateral (a) and contralateral side (b) to dIoN-CCI surgery compared with that of sham mice. c-d At 0.02 g stimulus intensity, mechanical pain hypersensitivity in dIoN-CCI mice was observed in the ipsilateral (c) and contralateral side (d) to dIoN-CCI surgery compared with that of sham mice. Data was expressed as Mean ± SEM. (n = 8 each group; *** P < 0.001 compared with the sham group, two-way ANOVA with post-hoc Bonferroni test). dIoN-CCI, chronic constriction injury of distal infraorbital nerve; BL, baseline

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The Journal of Headache and Pain

ISSN: 1129-2377

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