Fig. 1

Orofacial mechanical hypersensitivity following TNC and its inhibition by carbamazepine. a The trigeminal root following TNC. Arrows indicate the depressed region. I, II, and III indicate the location of neuronal soma innervating to the ophthalmic division, maxillary division, and the mandibular division, respectively. b The alteration of whisker pad skin MHWT bilateral to the TNC or sham procedure for 21 days. Data are presented as median, interquartile range (25–75 %), and maximum and minimum values. * p < 0.05 vs. sham. (n = 6 in each; Kruskal-Wallis followed by Dunn’s multiple comparisons test). c The suppressive effect of i.p carbamazepine administration on orofacial mechanical hypersensitivity on day 7 following TNC. Data are presented as median, interquartile range (25–75 %), and maximum and minimum values. * p < 0.05 vs. vehicle. (n = 6 in each; Kruskal-Wallis followed by Dunn’s multiple comparisons test)