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Fig. 6 | The Journal of Headache and Pain

Fig. 6

From: Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

Fig. 6

Statistical analysis of TRPV1 and nNOS staining 4 h after IS treatment The quantitative analysis shows that in the IS group the area covered by TRPV1 IR fibers and the number of nNOS IR cells is significantly higher than in the control group after 4 h. a Sumatriptan was able to attenuate the increase in TRPV1 IR fibers in the V/1 area. b Similar to sumatriptan kynurenic acid also mitigated the effect of IS in the V/1 area. c In the V/1 area sumatriptan was able to abolish the increase in nNOS IR cells. d Kynurenic acid also weakened the effect of IS in the V/1 area *p < 0.05; **p < 0.01, ***p < 0.001. * means SIF-IS differences, + means IS-SUMA/KYNA differences. SIF: synthetic interstitial fluid, IS: inflammatory soup, SUMASIF: sumatriptan + synthetic interstitial fluid, SUMAIS: sumatriptan + inflammatory soup, KYNSIF: kynurenic acid + synthetic interstitial fluid, KYNIS: kynurenic acid + inflammatory soup

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The Journal of Headache and Pain

ISSN: 1129-2377

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