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Table 3 Biochemical data of CM-MO patients before and after detoxification

From: Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine?

 

T0

T1

Statistical analysis

All patients

Responders

Non-responders

All patients

Responders

Non-responders

TIME

GROUP

TIME

x

GROUP

n

28

23

5

28

23

5

–

CGRP (pg/ml)

393.3 ± 242.9

322.9 ± 164.1

717.1 ± 301.1

275.2 ± 251.8

251.8 ± 383.2

383.2 ± 208.7

0.001

0.033

0.542

miR-382-5p (RQ)

14.6 ± 3.2

10.4 ± 1.1

33.9 ± 15.6

2.2 ± 0.4

1.7 ± 0.3

4.4 ± 1.1

0.001

0.009

0.344

miR-34a-5p (RQ)

69.5 ± 8.5

66.7 ± 8.8

81.8 ± 27.2

21.6 ± 4.0

20.7 ± 4.4

25.9 ± 10.4

0.001

0.775

0.804

  1. Legend: CM-MO chronic migraine with medication overuse. Responders: patients with a reduction of at least 30% of monthly migraine days after detoxification. T0: baseline evaluation; T1: 2 months after discharge from in-hospital detoxification. CGRP values are presented as mean ± standard deviation. microRNAs values are presented as “mean ± standard error of the mean”. RQ Relative quantification: 2−∆∆Ct = 2 − (∆Ct gene − ∆Ct housekeeping gene), Ct cycle threshold as defined in methods section. Statistical analysis: non-parametric tests for repeated measures with two factors: factor TIME (T0 vs. T1), and factor GROUP (responders vs. non-responders)
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The Journal of Headache and Pain

ISSN: 1129-2377

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