Fig. 8

Frequency of hospitalisations of patients with migraine in the German Company Sickness Fund Database by number of in-label preventive medications from different classes. Data are shown for all patients (overall) and patients grouped according to the number of restricted Group 1 (propranolol, metoprolol, flunarizine, topiramate and amitriptyline, but not onabotulinum toxin A or valproic acid) preventive medications from different classes prescribed during 2008–2016. n overall number of patients each year; patients were not required to be enrolled over the total study period (2008–2016), but were required to be continuously observable. For example, a person could enter the sample later than 2008 and leave it earlier than 2016