Fig. 1
From: Optimising migraine treatment: from drug-drug interactions to personalized medicine
Diclofenac metabolic profile. In the left column there is the list of drug metabolizing enzymes and drug transporters, one for each row; in the right column relationship between corresponding transporter or enzyme of the row and diclofenac: is indicated by the symbol ‘S’ for substrate, ‘Inh’ for inhibitor and ‘Ind’ for inducer. Enzymes CYP 2C9, CYP2C8 and UGT and transporter MRP2 (ABCC2) are rimmed to emphasize their importance in diclofenac’s metabolic destiny. Related page at the website http://bioinformatics.charite.de/transformer