Fig. 5
From: Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study
Functional connectivity of IC 3 (pain matrix) with the hypothalamus, DRN, and PAG. a Functional connectivity of IC 3 with the hypothalamus, dorsal raphe nuclei (DRN), and periaqueductal gray (PAG) are illustrated. The mean (SD) of edge values are shown and the width of the lines indicate the magnitude of edge weights. b Between-group analysis of connectivity between IC 3 and each region are summarized. Patients with CM showed a stronger connectivity between IC 3 and the hypothalamus (FDR-corrected p = 0.0399), whereas the connectivity between the DRN and IC 3 was stronger in patients with EM (FDR-corrected p = 0.0390). No between-group difference in the connectivity between IC 3 and the PAG were noted (FDR-corrected p = 0.2738)