Fig. 2

Efficacy of monoclonal antibodies in the preventive treatment of migraine. Bars indicated with * represents statistically significant values compared to placebo (p < 0.05). (1) had change in mean monthly migraine days from baseline to weeks 5–8 as the primary endpoint. All other studies had change in monthly migraine days from baseline to weeks 9–12 of the 12-week double-blind treatment phase as the primary endpoint. In (1) the drug/placebo was administered intravenously. In all other studies, the drug/placebo were given subcutaneously. (2) is on chronic migraine patients. All other studies are on episodic migraine patients