Table 1 Age and gender standardised risk of migraine without aura (MO), migraine with aura (MA), cluster headache (CH) and chronic tension-type headache (CTTH). The population relative risk is calculated by available data from the original articles by the author. The revised population relative risks on CH were calculated assuming the prevalence of cluster headache is 200 per 100.000 inhabitants [16]. CI denotes confidence intervals
Disease in proband | Study population | Disease in first-degree relative | No. of affected relatives Expected | Population relative risk (95% CI) | |
|---|---|---|---|---|---|
Observed | Expected | ||||
Migraine without aura | |||||
Mochi et al. [7] | Clinic | MO | 64 | 17.7 | 3.6 (1.1–6.1) |
Russell and Olesen [8] | General | MO | 102 | 54.8 | 1.9 (1.6–2.2) |
MA | 42 | 29.2 | 1.4 (1.0–1.9) | ||
Stewart et al. [10] | General | MO | 30 | 21.0 | 1.4 (0.8–2.5) |
MA | 10 | 4.2 | 2.4(0.9–4) | ||
Migraine with aura | |||||
Mochi et al. [7] | Clinic | MA | 13 | 1.9 | 7.0 (3.2–10.8) |
Russell and Olesen [8] | General | MA | 111 | 29.3 | 3.8 (3.2–4.4) |
MO | 56 | 54.9 | 1.0 (0.8–1.3) | ||
Kalfakis et al. [9] | Clinic | MA | 58 | 4.9 | 11.9 (7.0–16.7) |
Stewart et al. [10] | General | MA | 3 | 2.4 | 1.2 (0.3–5.5) |
MO | 17 | 12.1 | 1.4 (0.7–2.8) | ||
Chronic tension-type headache | |||||
Øtergaard et al. [11] | Clinic | CTTH | 71 | 22.6 | 3.1 (2.5–3.9) |
Cluster headache | |||||
Russell et al. [12] | Clinic | CH | 26 | 5.40 | 4.7 (3.1–6.9) |
CH* | 10 | 13.20 | 0.8 (0.4–1.4) | ||
Kudrow and Kudrow [13] | Clinic | CH | 41 | 2.70 | 15.2 (11.1–21.1) |
Leone et al. [14] | Clinic | CH | 39 | 2.97 | 13.1 (9.0–17.3) |
CH* | 18 | 6.69 | 2.7 (1.5–3.9) | ||
El Amrani et al. [15] | Clinic | CH | 22 | 1.25 | 17.6 (10.2–24.9) |